In the process of new drug research and development, the potential solid structure of the target compound is found through "screening", its physical and chemical properties are "adjusted" through the solid structure, and its in vitro and in vivo properties are "affected" through the solid physical and chemical properties, and then "evaluated", and finally the optimal solid shape is determined through the iterative cycle for development. An important means in the process is X-ray diffraction analysis.
XRD analysis is the use of crystal formation of X-ray diffraction, because the crystalline substance composition elements or groups are not the same or their structure is different, so that their diffraction spectra in Angle position, relative strength and diffraction peak shape will show differences, the internal atoms of the substance in the spatial distribution of structural analysis method.
This method has high sensitivity and fast analysis speed. The analysis of X-ray diffraction results helps us to understand the crystal condition and develop new drugs.In the development and evaluation of drugs with polycrystalline forms, the properties of a compound are determined by the understanding of its solid structure, and thus its specific properties.
