Powder X-ray diffraction, as one of the methods for the study of drug polymorphism, has the advantages of not destroying samples and simple operation, and is the main method for the qualitative and quantitative analysis of drug polymorphism at present.
The specific application of PXRD in the pharmaceutical industry
1 Qualitative analysis of unknown compounds
When a new drug is developed, researchers successfully synthesize a compound, they need to search whether the compound has been synthesized by others, and if it is confirmed that it is a new compound that has not been synthesized, then analyze it by other means.
Benchtop Powder X-ray Diffractometer(PXRD)
2 Analysis of drug crystal structure
Compound patents focus on the structural differences of compounds and their technical effects, while crystal patents emphasize the differences in the spatial arrangement of compound molecules and the resulting effect improvements.
3 Evaluate the crystallization of the original drug or the dispersion of the preparation
In order to improve the dissolution of drugs, it is technically possible to use hot melt extrusion technology for solid preparation of insoluble drugs and some carriers. At this time, PXRD can be used to directly characterize the degree of dispersion of the active ingredient in the solid preparation.
